The evaluation of endothelin 1 (EDN1) and endothelin receptor type A (EDNRA) gene polymorphisms in Hashimoto's thyroiditis

Aydın A. F. , Vural P. , Oruc C. U. , Dogru-Abbasoglu S. , OZDERYA A., KARADAG B., ...More

INTERNATIONAL IMMUNOPHARMACOLOGY, vol.21, no.1, pp.181-185, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.1016/j.intimp.2014.04.023
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.181-185
  • Keywords: Hashimoto's thyroiditis, Endothelin family, Polymorphism, Inflammation, KAPPA-B, ASSOCIATION, DISEASE


Purpose: Endothelin1 (EDN1) is well established marker of inflammation. The functions of EDN1 are mediated mainly by endothelin receptors type A (EDNRA). The etiopathogenesis of Hashimoto's thyroiditis (HT) remains still elusive although the role of chronic inflammation and subsequent endothelial dysfunction has been established. This study examined firstly the possible association of EDN1 (G5665T and T-1370G) and EDNRA (C+70G and G-231A) single nucleotide polymorphisms (SNPs) with the occurrence of HT, and evaluates the relationship between genotypes and clinical/laboratory manifestation of HT.