Evaluation of gonadal function in 107 intersex patients by means of serum antimullerian hormone measurement

Rey, RA; Belville, C; Nihoul-Fekete, C; Michel-Calemard, L; Forest, MG; Lahlou, N; Jaubert, F; Mowszowicz, I; David, M; Saka, N; Bouvattier, C; Bertrand, AM; Lecointre, C; Soskin, S; Cabrol, S; Crosnier, H; Leger, J; Lortat-Jacob, S; Nicolino, M; Rabl, W; Toledo, SPA; Bas, FİRDEVS; Gompel, A; Czernichow, P; Chatelain, P; Rappaport, R; Morel, Y; Josso, N

doi:10.1210/jc.84.2.627

Evaluation of gonadal function in 107 intersex patients by means of serum antimullerian hormone measurement

Rey R., Belville C., Nihoul-Fekete C., Michel-Calemard L., Forest M., Lahlou N., ...Daha Fazla

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, cilt.84, sa.2, ss.627-631, 1999 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 84 Sayı: 2
Basım Tarihi: 1999
Doi Numarası: 10.1210/jc.84.2.627
Dergi Adı: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.627-631
İstanbul Üniversitesi Adresli: Evet

Özet

Fetal male sexual differentiation is driven by two testicular hormones: testosterone (synthesized by interstitial Leydig cells) and antimullerian hormone (AMH; produced by Sertoli cells present in the seminiferous tubules). Intersex states result either from gonadal dysgenesis, in which both Leydig and Sertoli cell populations are affected, or from impaired secretion or action of either testosterone or AMH. Until now, only Leydig cell function has been assessed in children with ambiguous genitalia, by means of testosterone assay.