Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence
JOURNAL OF HYPERTENSION, vol.32, no.9, pp.1741-1750, 2014 (SCI-Expanded, Scopus)
- Publication Type: Article / Review
- Volume: 32 Issue: 9
- Publication Date: 2014
- Doi Number: 10.1097/hjh.0000000000000253
- Journal Name: JOURNAL OF HYPERTENSION
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1741-1750
- Istanbul University Affiliated: Yes
Abstract
Background and objectives: It is well established by a large number of randomized controlled trials that lowering blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) by drugs are powerful means to reduce stroke incidence, but the optimal BP and LDL-C levels to be achieved are largely uncertain. Concerning BP targets, two hypotheses are being confronted: first, the lower the BP, the better the treatment outcome, and second, the hypothesis that too low BP values are accompanied by a lower benefit and even higher risk. It is also unknown whether BP lowering and LDL-C lowering have additive beneficial effects for the primary and secondary prevention of stroke, and whether these treatments can prevent cognitive decline after stroke.