Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside

OZKAN A., APAK H., Celkan T. T., YUKSEL L., YILDIZ i.

PEDIATRIC DERMATOLOGY, cilt.18, sa.1, ss.38-40, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1046/j.1525-1470.2001.018001038.x
  • Dergi Adı: PEDIATRIC DERMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.38-40
  • İstanbul Üniversitesi Adresli: Evet

Özet

We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C), A 13-year-old girl with acute lymphocytic leukemia was treated according to the protocol of the BFM Group (BFM-95, HRG), On the fifth day after administration of a high dose of ARA-C (2 g/m(2) intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day, ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.