Ultrastructural evaluation of intramuscular applied botulinum toxin type A in striated muscles of rats.


Kocaelli H., Yaltirik M., Ayhan M., Aktar F., Atalay B., Yalçın S.

Hippokratia, cilt.20, sa.4, ss.292-298, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 4
  • Basım Tarihi: 2016
  • Dergi Adı: Hippokratia
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.292-298
  • Anahtar Kelimeler: Botulinum toxin type A, muscular changes, myofibrils, ultrastructure, electron microscopy, atrophy, degeneration
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Botulinum toxin type A (BTX-A) is clinically utilized for therapeutic and cosmetic purposes in maxillofacial surgery as well as many other medical specialties. There is no sufficient ultrastructural research about BTX and it is controversial whether BTX-A causes muscle degeneration to some extent, in the course of therapy. The aim of this study was to evaluate the histological effects of BTX-A when injected into masseter and gluteal muscles.