Inflammatory Mediators Across the Spectrum of Ankle-Brachial Index

Gur D. O., GÜR Ö., Guzel S., Akyuz A., GÜRKAN S., ALPSOY Ş., ...Daha Fazla

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, cilt.26, sa.4, ss.351-361, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5551/jat.44891
  • Dergi Adı: JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.351-361
  • İstanbul Üniversitesi Adresli: Evet

Özet

Aim: Peripheral artery disease (PAD) is a manifestation of atherosclerosis with poor prognosis. It is generally complicated by vascular calcification, which is located either in the intima as patchy infiltrates; or circumferentially in the media, also known as medial arterial calcification (MAC). Obstructive PAD is reflected by low ankle-brachial index (ABI <= 0.9), whereas MAC is revealed by high ABI (ABI > 1.4). Considering the increase in cardiovascular mortality at both ends of the ABI spectrum, this study aimed to explore the underlying pathology through cytokines with established prognostic significance; namely pentraxin-3(PTX3), high sensitivity C-reactive protein (hsCRP), copeptin, soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), NT-proBNP, and neopterin.