Evaluation of A Fluorescence Screening Method in The Detection of Oral Pre- and Malignant Lesions


Erçalık Yalçınkaya Ş., Aksakallı F. N. , Elçin M. A. , Dumlu A., Alatlı F. C. , Özbayrak S.

17th International Congress on Oral Pathology and Medicine Joint Meeting of the British Society for Oral & Maxillofacial Pathology, İstanbul, Turkey, 25 - 30 May 2014, vol.119, no.3, pp.175

  • Publication Type: Conference Paper / Full Text
  • Volume: 119
  • Doi Number: 10.1016/j.oooo.2014.07.324
  • City: İstanbul
  • Country: Turkey
  • Page Numbers: pp.175

Abstract

Objective

The aim of this prospective study was to evaluate the accuracy of VELscope® (VE) and its capacity to assess oral dysplasia and malignancy compared to histopathological examination.

Study Design

A total of 135 patients with 170 suspicious oral lesions attending to an oral diagnosis clinic subjected to standard oral examination (OE). Lesions were evaluated with VE, followed by smear and biopsy. The combination of OE and VE diagnoses was assessed and compared to the diagnoses based on the histopathology.

Results

Compared to histopathology, the sensitivity of VE was 93.06%, the specificity was 56.12%. The combination of OE and VE findings was significantly correlated with the gold standard, histopathology (Mc Nemar's test, p=1.0). When compared to histopathology, the sensitivity and specificity of OE+VE were 87.5% and 89.8%, respectively, whereas PPV and NPV were 86.3% and 90.72%, respectively.

Conclusions

Combination of OE+VE appear to be effective for aiding the diagnosis of potentially malignant lesions.