MCP-1 and CCR2 Gene Variants and the Risk for Osteoporosis and Osteopenia

Eraltan H., Cacina C. , Kahraman O. T. , Kurt Ö. , Aydogan H. Y. , Uyar M., ...Daha Fazla

GENETIC TESTING AND MOLECULAR BIOMARKERS, cilt.16, ss.229-233, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 16 Konu: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1089/gtmb.2011.0216
  • Sayfa Sayıları: ss.229-233


Aim: In this study, we investigated whether monocyte chemotactic protein 1 (MCP-1) and CC chemokine receptor 2 (CCR2) gene polymorphisms account for an increased risk of osteoporosis or osteopenia. Methods: Three hundred three postmenopausal women, 80 osteoporotic, 123 osteopenic, and 100 unrelated age-matched healthy controls, were included in the study. Genotyping of MCP-1 A2518G and CCR2 V64I gene polymorphisms were detected by PCR-RFLP. Results: We, for the first time, demonstrated the positive association of MCP-1 GG, CCR2 Val/Ile, and CCR2 Val+ genotype with osteoporosis risk. However, CCR2 Ile/Ile genotype frequencies were high in the control group compared with those of the patients with osteoporosis and osteopenia. Haplotype analysis confirmed the association of MCP-1/CCR2 gene variants with osteopenia and revealed that the frequency of MCP-1 A: CCR2 Val haplotype was significantly higher in patients when compared with controls. Conclusions: In conclusion, our findings have suggested that MCP-1 and CCR2 gene variants were risk factors for osteoporosis and osteopenia.