Effect of magnesium, MK-801 and combination of magnesium and MK-801 on blood-brain barrier permeability and brain edema after experimental traumatic diffuse brain injury

Imer, Murat; Omay, Bulent; Uzunkol, Ajlan; Erdem, Tulin; Sabanci, PULAT; Karasu, Aykut; Albayrak, Serdar; Sencer, ALTAY; Hepgul, Kemal; Kaya, Mehmet

doi:10.1179/174313209x385617

Effect of magnesium, MK-801 and combination of magnesium and MK-801 on blood-brain barrier permeability and brain edema after experimental traumatic diffuse brain injury

Imer M., Omay B., Uzunkol A., Erdem T., Sabanci P. A., Karasu A., ...Daha Fazla

NEUROLOGICAL RESEARCH, cilt.31, sa.9, ss.977-981, 2009 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 31 Sayı: 9
Basım Tarihi: 2009
Doi Numarası: 10.1179/174313209x385617
Dergi Adı: NEUROLOGICAL RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.977-981
Anahtar Kelimeler: Diffuse brain injury, blood-brain barrier, brain edema, magnesium, MK-801, FOCAL CEREBRAL-ISCHEMIA, EXPERIMENTAL HEAD TRAUMA, ACUTE SUBDURAL-HEMATOMA, D-ASPARTATE ANTAGONISTS, RATS, THERAPY, INFARCTION, SULFATE, MODEL, REDUCTION
İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Glutamate antagonists are very attractive drugs in laboratory works to protect neural tissue against ischemia. In this work, the effects of magnesium, MK-801 and combination of magnesium and MK-801 on blood-brain barrier (BBB) and brain edema after experimentally induced traumatic brain injury are evaluated.