Expression of angiogenic growth factors in canine squamous cell cancers

Sozmen M., Devrim A. K., Sudagidan M., Kabak Y. B., Yildirim F.

BIOTECHNIC & HISTOCHEMISTRY, cilt.96, sa.6, ss.450-459, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 96 Sayı: 6
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/10520295.2020.1818826
  • Dergi Adı: BIOTECHNIC & HISTOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.450-459
  • Anahtar Kelimeler: Angiogenesis, bFGF, canine, growth factors, PDGF, squamous cell carcinoma, TGFβ1, VEGF-C
  • İstanbul Üniversitesi Adresli: Evet

Özet

Skin and subcutaneous tissue tumors are the most common neoplasms in dogs. The most common sites of origin in dogs include digits, skin and the oral cavity including cheek and retromandibular area. We investigated canine squamous cell carcinoma (SCC) samples from 15 dogs and classified them histopathologically according to the degree of differentiation. bFGF, VEGF-C, TGF-beta, PDGF-A, PDGF-C and PDGFR-alpha expressions were assessed using immunohistochemistry to determine the roles of growth factors during SCC. We found that TGF-beta 1 immunolabeling was elevated significantly compared to healthy controls in SCC originating from nailbeds, while expression of other growth factors did not change significantly. Our findings might explain the role of TGF-beta 1 in the infiltrative and malignant behavior of SCC originating from nailbeds.