Sex- and Obesity-specific Association of Aromatase (CYP19A1) Gene Variant with Apo lipoprotein B and Hypertension

Coban N., Onat A., Guclu-Geyik F., Can G., Erginel-Unaltuna N.

ARCHIVES OF MEDICAL RESEARCH, cilt.46, sa.7, ss.564-571, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 7
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.arcmed.2015.09.004
  • Dergi Adı: ARCHIVES OF MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.564-571
  • Anahtar Kelimeler: Apolipoprotein B, CYP19A1 polymorphism, Insulin resistance, Sex disparity, TARF study, METABOLIC SYNDROME, ABDOMINAL OBESITY, ESTROGEN-LEVELS, BLOOD-PRESSURE, BODY-MASS, RISK, POLYMORPHISM, DISEASE, BREAST, HEART
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background and Aims. Gender differences in cardiovascular disease risk have been attributed to sex hormones. The CYP19A1 protein (aromatase) plays a critical role in estrogen biosynthesis and thus affects body fat distribution and regulation. We examined the relationship between polymorphism of the CYP19A1 gene and lipoproteins, body mass index (BMI), insulin levels and HOMA index.