The effect of CTLA-4 and CD28 gene variants and circulating protein levels in patients with gastric cancer

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Arikan S., Gumus A., Kucukhuseyin O., Coskun C., Turan S., Cacina C., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.42, sa.5, ss.551-558, 2017 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 42 Sayı: 5
• Basım Tarihi: 2017
• Doi Numarası: 10.1515/tjb-2017-0024
• Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.551-558
• Anahtar Kelimeler: Cluster of differentiation 28 (CD28), Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), Gastric cancer, Polymerase chain reaction (PCR), Single nucleotide polymorphism (SNPs), T-LYMPHOCYTE ANTIGEN-4, CERVICAL-CANCER, BREAST-CANCER, RHEUMATOID-ARTHRITIS, EXON-1 POLYMORPHISMS, MULTIPLE-SCLEROSIS, ASSOCIATION, EXPRESSION, SUSCEPTIBILITY, CELLS
• İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Gastric cancer is one of the most common malignancies worldwide. The risk factors for gastric cancer include environmental and genetic factors. Inflammation and the immune system are known to contribute to the development of the gastric cancer. We examined the influence of critical polymorphisms of CTLA-4 and CD28 genes and circulating protein levels on the etiology of gastric cancer.