Investigation of <i><u>MBL2</u></i> and <i><u>NOS3</u></i> functional gene variants in suspected COVID-19 PCR (-) patients.

Creative Commons License

Pehlivan S., Köse M., Mese S., Serin I., Senkal N., Oyacı Y., ...Daha Fazla

Pathogens and global health, cilt.116, sa.3, ss.178-184, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 116 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/20477724.2021.1984726
  • Dergi Adı: Pathogens and global health
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.178-184
  • Anahtar Kelimeler: COVID-19, mannose-binding lectin 2 (MBL2), endothelial nitric oxide synthase (eNOS), PCR, CT, MANNOSE-BINDING LECTIN, ASSOCIATION, POLYMORPHISMS, SUSCEPTIBILITY, DEFICIENCY, MUTATIONS
  • İstanbul Üniversitesi Adresli: Evet

Özet

For COVID-19 (Coronavirus Disease-2019) cases, detecting host-based factors that predispose to infection is a very important research area. In this study, the aim is to investigate the MBL2 and NOS3 gene polymorphisms in COVID-19 patients with lung involvement, whose first nasopharyngeal PCR results were negative. Seventy-nine patients diagnosed with COVID-19 between April-June 2020 who were admitted to a university hospital, and 100 healthy controls were included. In the first statistical analysis performed between PCR-positive, CT-negative and PCR-negative, CT-positive patients; the AB of MBL2 genotype was significantly higher in the first group (p = 0.049). The B allele was also significantly higher in the same subgroup (p = 0.001). The absence of the AB genotype was found to increase the risk of CT positivity by 6.9 times. The AB genotype of MBL2 was higher in healthy controls (p = 0.006). The absence of the AB genotype was found to increase the risk of CT positivity; also, it can be used for early detection and isolation of patients with typical lung involvement who had enough viral loads, but whose initial PCR results were negative.