Cytokine Secretion and Proliferative Capacity of CD4(+) T Cells in Delayed Type Hypersensitivity Reactions due to Ciprofloxacin

Ertek B., DEMİR S., KÜÇÜKSEZER U. C., Ozyigit L. P., GELİNCİK A., Buyukozturk S., ...Daha Fazla

TURKISH JOURNAL OF IMMUNOLOGY, cilt.8, sa.3, ss.120-128, 2020 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.25002/tji.2020.1339
  • Dergi Adı: TURKISH JOURNAL OF IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.120-128
  • Anahtar Kelimeler: Allergy, CD4(+) T cells, ciprofloxacin, hypersensitivity, intracellular cytokine, LTT, LYMPHOCYTE-TRANSFORMATION TEST, DRUG HYPERSENSITIVITY, FLUOROQUINOLONES ANALYSIS, SAFETY PROFILE, IFN-GAMMA, DIAGNOSIS, QUINOLONES, RELEASE, TESTS, IL-5
  • İstanbul Üniversitesi Adresli: Evet

Özet

Introduction: Ciprofloxacin (CPFX), a frequently prescribed quinolone, may induce cutaneous adverse drug reactions. Delayed type hypersensitivity reactions (DTHR) are often difficult to deal with, therefore, in vitro testing for DTHR is the long-anticipated method for their management. This study aimed to evaluate potential value of lymphocyte transformation t est (LTT) and intracellular cytokine secretion of drug srimulared CD4(+ )T cells in patients with DTHR against ciprofloxacin.