Akademik Veri Yönetim Sistemi
Istanbul Tip Fakultesi Mecmuasi, cilt.57, sa.3, ss.44-48, 1994 (Scopus)
To assess the involvement of glycation in diabetic nephropathy, we studied glycated albumin (GA), glycated hemoglobin (GHb), and fructosamine (FA) in 46 diabetic patients (26 type 1 and 20 type 2) with mean age of 40.19 ± 20.14 yrs (range 14-80 yrs) and mean diabetes duration of 9.55 ± 6.90 years (range 1, 24 yrs) and 10 healthy control subjects with mean age of 30.55 ± 9.64 years (range 20-46 yrs). On the basis of microalbuminuria, creatinine clearance and clinical findings the patients were subdivided into groups of non-nephropathy (n:13), initial (n:9), overt (n:11) and severe-nephropathy (n:13). Glycation parameters were all found to be higher (p=0.001) in diabetic patients than in controls. These parameters were not correlated in controls whereas GA and FA were correlated (r=0.30, p<0.05) in diabetics. On comparison of groups of non-nephropathy vs. nephropathy GHb and FA, but not GA, were found to be higher In the nephropathy group, however GA was elevated (p<0.02) only in the initial nephropathy group. By comparison of groups with different stages of nephropathy only for FA, a difference (p<0.01) was noted (between severe-overt nephropathy groups). Additionally,, GHb was only found to be correlated with FA (r=0.78, 0.01>p>0.001) in the severe nephropathy group. In conclusion, these results suggest careful interpretation of glycation findings in relation to diabetic nephropathy.