Polyelectrolyte Multilayers Composed of Polyethyleneimine-Grafted Chitosan and Polyacrylic Acid for Controlled-Drug-Delivery Applications

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Paker E. S., Senel M.

JOURNAL OF FUNCTIONAL BIOMATERIALS, vol.13, no.3, 2022 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 13 Issue: 3
• Publication Date: 2022
• Doi Number: 10.3390/jfb13030131
• Journal Name: JOURNAL OF FUNCTIONAL BIOMATERIALS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Applied Science & Technology Source, BIOSIS, Communication Abstracts, EMBASE, INSPEC, Metadex, Directory of Open Access Journals, Civil Engineering Abstracts
• Keywords: layer-by-layer film, chitosan, polyethylene imine, polyacrylic acid, drug delivery, LAYER, IMMOBILIZATION, MOLECULES, RELEASE, BINDING
• Open Archive Collection: AVESIS Open Access Collection
• Istanbul University Affiliated: No

Abstract

In this work, polyethyleneimine (PEI)-grafted chitosan (Chi-g-PEI) was prepared for the fabrication of layer-by-layer (LBL) films for use in sustained-drug-delivery applications. Chi-g-PEI and polyacrylic acid (PAA) multilayer films were formed using the LBL technique. Methylene blue (MB) was used as a model drug for the investigation of loading and release capabilities of the LBL films. Characterizations of the synthesized copolymer were performed using Fourier-transform infrared spectroscopy (FTIR), Nuclear magnetic resonance spectroscopy (NMR), Thermogravimetric analysis (TGA), and X-ray Powder Diffraction (XRD) techniques, and the thickness of the LBL films was measured using Atomic force microscopy (AFM). The drug-loading and -release behaviors of the LBL films were assessed using a UV-visible spectrophotometer. The results showed that the loading capacity and release rate of MB were affected by ionic strength and pH. In addition, it was demonstrated that PEI-grafted chitosan is a good candidate for the assembling of LBL films for drug-delivery applications.