Examination of the apoptotic effects of betulinic acid on renal cancer cell lines

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Ergen A., Iplik E. S., ERTUĞRUL B., Atas M. N., Kasarci G., ÇAKMAKOĞLU B.

MARMARA MEDICAL JOURNAL, cilt.33, sa.3, ss.113-118, 2020 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5472/marumj.815542
  • Dergi Adı: MARMARA MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.113-118
  • Anahtar Kelimeler: Renal cancer, Betulinic acid, Apoptosis, ACHN, CAKI-2, MITOCHONDRIA
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Renal cancers are highly resistant to standard hormonal therapy, radiotherapy, and chemotherapy, and the survival rates are extremely low. Betulinic acid is a pentasilic triterpenoid saponin of lupine type obtained from various natural plants, especially from the shell of Betula plant. Betulinic acid was shown both in in vivo, and in vitro to have the ability to induce apoptotic pathways causing no toxicity for normal cells, and also has immunomodulatory effects. The aim of the present project is to investigate the anticancer effects of betulinic acid on CAKI-2 (ATCC (R) HTB-47T; clear cell renal carcinoma), ACHN (ATCC (R) CRL-1611T; renal cell adenocarcinoma) and MRC-5 (ATCC (R) CCL-171T: normal lung fibroblast) cell lines.