Other, pp.1-5, 2018
The role of Nitric Oxide (NO) in tumor biology is not well
understood. However, it has been proposed that NO is a highly
reactive free radical and plays important roles in growth, progression
or metastasis of tumour. Nitric oxide syntheses (NOSs) are a family of
enzymes that catalyzing the production of NO by converting L-arginine
to L-citrulline. The aim of present study was to examine Nitric Oxide
Synthase 3 (NOS3) Glu298Asp polymorphism in patients with breast
cancer. For this purpose, 49 patients with breast cancer and 89
healthy controls were included in the study. The NOS3 Glu298Asp
polymorphism was genotyped by PCR-RFLP using peripheral blood
samples in our study groups. NOS3 Glu298Asp genotype distribution
in the breast cancer patients was statistically different from the healthy
control group NOS3 Glu298Asp gene variation T allele frequency
was significantly higher in breast cancer patients that of controls.
Our finding suggests that NOS3 Glu298Asp might be associated with
breast cancer risk.