THE EFFECTS OF ALPHA LIPOIC ACID ON LENS INJURY IN RATS ADMINISTERED WITH VALPROIC ACID

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Oztaylan Y., Turkyilmaz I. B., Yanardag R.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, vol.85, pp.557-563, 2022 (ESCI)

• Publication Type: Article / Article
• Volume: 85
• Publication Date: 2022
• Doi Number: 10.26650/iuitfd.1073100
• Journal Name: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
• Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.557-563
• Keywords: Valproic acid, alpha lipoic acid, lens tissue, oxidative stress, ALDOSE REDUCTASE, VITAMIN U, ANTIOXIDANT, GLUTATHIONE, SULFUR
• Open Archive Collection: AVESIS Open Access Collection
• Istanbul University Affiliated: Yes

Abstract

Objective: Valproic acid (2-propyl valeric acid; VPA) is an effective short-chained fatty acid which is used for the treatment of migraine and schizophrenia. Though it provides effective treatment, its side effects are associated with free radicals and in this way it affects many organs and tissues. Alpha lipoic acid (ALA) is known to be a powerful antioxidant.