Whole-genome screening for susceptibility genes in multicase families with Behcet's disease
ARTHRITIS AND RHEUMATISM, cilt.52, sa.6, ss.1836-1842, 2005 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 52 Sayı: 6
- Basım Tarihi: 2005
- Doi Numarası: 10.1002/art.21060
- Dergi Adı: ARTHRITIS AND RHEUMATISM
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1836-1842
- İstanbul Üniversitesi Adresli: Evet
Özet
Objective. Behcet's disease is generally considered to be a multifactorial disease with important genetic and environmental components. A strong association between an HLA class I antigen, HLA-B51, and Behcet's disease has long been known. However, analysis of multicase families has suggested a substantial contribution of non-HLA loci. The aim of this study was to perform a whole-genome linkage analysis for identification of other susceptibility loci for Behcet's disease in multicase families.