Whole-genome screening for susceptibility genes in multicase families with Behcet's disease

KARASNEH J., Gul A., OLLIER W., SILMAN A., WORTHINGTON J.

ARTHRITIS AND RHEUMATISM, cilt.52, sa.6, ss.1836-1842, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 6
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1002/art.21060
  • Dergi Adı: ARTHRITIS AND RHEUMATISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1836-1842
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective. Behcet's disease is generally considered to be a multifactorial disease with important genetic and environmental components. A strong association between an HLA class I antigen, HLA-B51, and Behcet's disease has long been known. However, analysis of multicase families has suggested a substantial contribution of non-HLA loci. The aim of this study was to perform a whole-genome linkage analysis for identification of other susceptibility loci for Behcet's disease in multicase families.