SIROLIMUS ASSOCIATED INTERSTITIAL PNEUMONITIS IN A RENAL TRANSPLANT PATIENT: IS ITAHYPERSENSITIVITY RESPONSE?

Caliskan Y., Ecder S. A., Guven D., Ozkan O., Ecder T., TÜRKMEN A., ...Daha Fazla

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, cilt.70, sa.1, ss.19-22, 2007 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Sayı: 1
  • Basım Tarihi: 2007
  • Dergi Adı: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.19-22
  • Anahtar Kelimeler: Interstitial pneumonitis, sirolimus, renal transplantation, immunosuppressive drugs
  • İstanbul Üniversitesi Adresli: Evet

Özet

Sirolimus is a maintenance immunosuppressive agent after renal transplantation. Interstitial pneumonitis due to sirolimus which had no identified infectious etiology has been recently reported. We describe a case of recurrent sirolimus associated interstitial pneumonitis after renal transplantation, on the basis of its mechanism of action. The diagnosis of sirolimus-associated pulmonary toxicity was made after an exhaustive work-up to exclude infectious causes and other pulmonary disease. Sirolimus discontinuation resulted in clinical and radiologic improvement of interstital pneumonitis within 2 weeks. The precise etiology underlying sirolimus-induced pneumonitis remains unknown. However, observations in animals and humans indicate that this agent may cause lung injury in selected cases via differential regulation of the Th1/Th2 lymphocyte balance. We thought that bronchoalveolar lavage cell counts may provide some information about the mechanism of sirolimus-induced pneumonitis.