Isolated Adrenal Metastases of Castration-Resistant Prostate Cancer

Topal E., Has Simsek D., Vatansever S., Sanli Y., Kuyumcu S.

CLINICAL NUCLEAR MEDICINE, sa.1, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1097/rlu.0000000000004964
  • Dergi Adı: CLINICAL NUCLEAR MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • İstanbul Üniversitesi Adresli: Evet

Özet

We present isolated bilateral adrenal metastases successfully treated with Lu-177-PSMA in a 66-year-old man diagnosed with castration-resistant prostate cancer. The patient had progression under chemotherapy as depicted by Ga-68-PSMA PET/CT showing intense bilateral PSMA uptake in the adrenal masses, and metastasis-directed therapies were considered as the first option for improving survival because the patient was oligometastatic. However, surgery and radiotherapy were not justifiable options due to the high risk of definitive adrenal insufficiency; therefore, the patient received 4 cycles of Lu-177-PSMA treatment. Ga-68-PSMA PET/CT showed near-complete response in bilateral adrenal metastases, and no sign of adrenal insufficiency was observed during follow-up.