CHARACTERIZATION OF SUSPICIOUS MICROCALCIFICATIONS ON MAMMOGRAPHY USING 2D SHEAR-WAVE ELASTOGRAPHY

Kayadibi Y. A. S. E. M. I. N., Ucar N. E. S. E., Kaya M. F., Yildirim E. M. I. N. E., Bektas S. I. B. E. L.

ULTRASOUND IN MEDICINE AND BIOLOGY, vol.47, no.9, pp.2532-2542, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 9
  • Publication Date: 2021
  • Doi Number: 10.1016/j.ultrasmedbio.2021.05.008
  • Journal Name: ULTRASOUND IN MEDICINE AND BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CINAHL, Compendex, EMBASE, MEDLINE
  • Page Numbers: pp.2532-2542
  • Keywords: Breast cancer, Ductal carcinoma in situ, Invasive ductal carcinoma, Microcalcifications, Shear-wave elastography, CARCINOMA IN-SITU, SONOGRAPHICALLY GUIDED BIOPSY, POSITIVE PREDICTIVE-VALUE, ULTRASOUND ELASTOGRAPHY, BREAST-LESIONS, CLINICAL-USE, WFUMB GUIDELINES, US, CANCER, RECOMMENDATIONS
  • Istanbul University Affiliated: No

Abstract

Our aim was to investigate the correlations between the findings of two-dimensional shear-wave elastography (2D-SWE) and the histopathologic results of microcalcifications (MCs) visualized using ultrasonography (USG). Fifty people with suspicious MCs without accompanying mass were evaluated. They underwent USG and 2D-SWE before USG-guided tru-cut biopsy. SWE values and histopathologic features were compared statistically. The variables between groups were analyzed using the Mann-Whitney U test. Receiver operating characteristic analysis was performed and cut-off values determined to discriminate malignancy, invasiveness and high grade. Pathology confirmed 27 malignant lesions (18 invasive ductal carcinomas, one invasive lobular and eight ductal carcinomas in situ) and 23 benign ones. There was a statistically significant difference between the SWE values of malignant and benign MCs (p < 0.001). The diagnostic performance of SWE for malignancy, invasiveness and high grade were as follows, repectively: sensitivity (93%, 83%, 88%), specificity (91%, 88%, 53%), positive predictive value (93%, 94%, 44%), negative predictive value (91%, 70%, 90%) and area under the curve (0.952, 0.885, 0.776). Cut-off values were determined as 57 kPa for malignancy, 124 kPa for invasiveness and 124.5 kPa for high grade. In conclusion, SWE is a useful method in clinical practice for characterizing MCs that can be visualized with USG. (C) 2021 World Federation for Ultrasound in Medicine & Biology. All rights reserved.