Effect of stage 2 kindling on local cerebral blood flow rates in rats with genetic absence epilepsy


Carcak N., Ferrandon A., KONING E., Aker R. G., Oezdemir O., Onat F. Y., ...More

EPILEPSIA, vol.50, no.1, pp.33-43, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1111/j.1528-1167.2008.01712.x
  • Journal Name: EPILEPSIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.33-43
  • Keywords: Limbic seizures, Epileptogenesis, Kindling-resistance, Spike-and-wave discharges, [C-14]-iodoantipyrine, ELECTRICAL-STIMULATION, ENTORHINAL CORTEX, WAVE DISCHARGES, TEMPORAL-LOBE, SEIZURES, MODEL, BRAIN, METABOLISM, MECHANISMS, GLUTAMATE
  • Istanbul University Affiliated: Yes

Abstract

Genetic absence epilepsy rats from Strasbourg (GAERS) are resistant to the progression of kindling seizures. We studied local cerebral blood flow (LCBF) changes in brain regions involved in seizures in both GAERS and nonepileptic rats (NEC) to map the differences that may be related to the resistance to kindling.