DHRS2 is a potential marker of breast cancer metastasis

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Yaylaz B. S., Ekmekci S. S., ÇINAR S., DENİZ G., ABACI N.

GENE REPORTS, cilt.25, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.genrep.2021.101302
  • Dergi Adı: GENE REPORTS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, BIOSIS, EMBASE
  • Anahtar Kelimeler: DHRS2, Migration, MCF7, Breast cancer, RNAi, TARGET GENE, HEP27, MDM2, P53, EXPRESSION, PROTEIN, GROWTH, MEMBER, CELLS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Although breast cancer treatment success has increased, biomarkers are still important. The dehydrogenase/reductase DHRS2 has a role in the metabolic and survival activities of cells. DHRS2 directly binds MDM2 and inhibits the cellular processes of p53. Our study aimed to examine cellular response to inhibit DHRS2 gene expression in the breast cancer cell line MCF7.