Myocardial Performance Index and Carotid Intima-Media Thickness in Children with Metabolically Healthy and Metabolically Unhealthy Obesity
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, cilt.18, sa.3, ss.402-409, 2026 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.4274/jcrpe.galenos.2025.2025-5-4
- Dergi Adı: JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Sayfa Sayıları: ss.402-409
- İstanbul Üniversitesi Adresli: Evet
Özet
Objective: To compare the myocardial performance index (MPI) and carotid intima-media thickness (cIMT) of children who are metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO) with children without obesity. Methods: This study included obese patients between 6 and 17 years of age and age-and gender-matched healthy children. Two groups of obese patients were investigated: MUO and MHO. Results: There were 62 obese (MUO=30; MHO=32) and 30 healthy controls included. Compared to controls, the MPI score and cIMT of both obese groups were significantly larger (p=0.004 and p=0.003, respectively). However, there was no significant difference in MPI and cIMT between the MUO and MHO groups. Moreover, there were independent associations between higher MPI and body mass index-standard deviation score (BMI-SDS) ((3=0.312, p=0.002) and between higher cIMT and waist circumference-SDS (WC-SDS) ((3=0.371, p=0.003). Conclusion: The primary outcome of the study indicated that while both MPI and cIMT values were elevated in obese children compared to non-obese controls, there was no significant difference between MUO and MHO groups. This suggests that obesity itself, irrespective of metabolic health, is associated with increased cardiovascular risks. BMI-SDS and WC-SDS were useful markers for identifying children at cardiovascular risk in this cohort.