An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype


Direk N. , Williams S., Smith J. A. , Ripke S., Air T., Amare A. T. , ...Daha Fazla

BIOLOGICAL PSYCHIATRY, cilt.82, ss.322-329, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 82 Konu: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.biopsych.2016.11.013
  • Dergi Adı: BIOLOGICAL PSYCHIATRY
  • Sayfa Sayıları: ss.322-329

Özet

BACKGROUND: The genetics of depression has been explored in genome-wide association studies that focused on either major depressive disorder or depressive symptoms with mostly negative findings. A broad depression phenotype including both phenotypes has not been tested previously using a genome-wide association approach. We aimed to identify genetic polymorphisms significantly associated with a broad phenotype from depressive symptoms to major depressive disorder.