Spectrophotometric determination of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors in pharmaceutical preparations

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Ergin Kızılçay G., Çağlar Andaç S., Önal A., Toker S.

Turkish Journal of Chemistry, vol.37, pp.171-181, 2013 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 37
  • Publication Date: 2013
  • Journal Name: Turkish Journal of Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.171-181
  • Istanbul University Affiliated: Yes

Abstract

Simple and accurate spectrophotometric methods are presented for the determination of five 3-hydroxy-3- methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors (statins), namely atorvastatin, fluvastatin, pitavastatin, rosuvastatin, and simvastatin, in pharmaceutical preparations. The methods are based on the reaction of drugs as n-electron donor with 7,7,8,8-tetracyanoquinodimethane as π-acceptors to give highly colored complex species. All variables were studied in order to optimize the reaction conditions. Beer’s law was obeyed in the concentration ranges 4–20 μg mL −1 , 4–12 μg mL −1 , 0.8–2.4 μg mL −1 , 4–14 μg mL −1 , and 2.5–20 μg mL −1 for atorvastatin, fluvastatin, pitavastatin, rosuvastatin, and simvastatin, respectively. The proposed methods were successfully applied to the pharmaceutical preparations without any interference from excipients.