Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy


Dallmann R., Okyar A. , Leyi F.

TRENDS IN MOLECULAR MEDICINE, cilt.22, ss.430-445, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 22 Konu: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.molmed.2016.03.004
  • Dergi Adı: TRENDS IN MOLECULAR MEDICINE
  • Sayfa Sayıları: ss.430-445

Özet

Daily rhythms in physiology significantly modulate drug pharmacokinetics and pharmacodynamics according to the time-of-day, a finding that has led to the concept of chronopharmacology. The importance of biological clocks for xenobiotic metabolism has gained increased attention with the discovery of the molecular circadian clockwork. Mechanistic understanding of the cell-autonomous molecular circadian oscillator and the circadian timing system as a whole has opened new conceptual and methodological lines of investigation to understand first, the clock's impact on a specific drug's daily variations or the effects/side effects of environmental substances, and second, how clock-controlled pathways are coordinated within a given tissue or organism. Today, there is an increased understanding of the circadian modulation of drug effects. Moreover, several molecular strategies are being developed to treat disease-dependent and drug-induced clock disruptions in humans.