THE EFFECT OF PARENTERAL PENTOXIFYLLINE THERAPY ON SKIN FLAP SURVIVAL

TOPALAN M., ARINCI A., ERER M., GUVENC H.

EUROPEAN JOURNAL OF PLASTIC SURGERY, vol.16, no.1, pp.33-35, 1993 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 1
  • Publication Date: 1993
  • Doi Number: 10.1007/bf00192704
  • Journal Name: EUROPEAN JOURNAL OF PLASTIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.33-35
  • Istanbul University Affiliated: No

Abstract

The effect of pentoxifylline as a hemorrheologic agent on skin flap survival has been observed. A caudally pedicled dorsal flap with an ischemic component in rats was used as the model. The flap survival was calculated to be 0.807+/-0.049 in the control group (n = 15), where flap survival was found to be 0.9713+/-0.018 in the pentoxifylline treated group (n = 15) (t = 12.19, p < 0.005). In the meantime, living flap length was measured as 9.96+/-0.72 in the control group, and 11.84+/-0.18 in the pentoxifylline treated group. With these results, we have come to the conclusion that parenteral pentoxifylline therapy is effective on ischemic skin flap survival in the rat model.