The effects of age and gender on the relationship between HMGCR promoter-911 SNP (rs33761740) and serum lipids in patients with coronary heart disease

Akadam-Teker B., Kurnaz Ö., Coskunpinar E., Daglar-Aday A., Kucukhuseyin O., Cakmak H. A., ...More

GENE, vol.528, pp.93-98, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 528
  • Publication Date: 2013
  • Doi Number: 10.1016/j.gene.2013.07.056
  • Journal Name: GENE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.93-98
  • Keywords: HMGCR, Polymorphism, Lipoproteins, Coronary heart disease, ACUTE MYOCARDIAL-INFARCTION, COA REDUCTASE, LOWERING RESPONSE, GENE, RISK, POLYMORPHISM, CHOLESTEROL, COENZYME, RECEPTOR
  • Istanbul University Affiliated: Yes

Abstract

Background: Hydroxymethylglutaryl-Coenzyme A Reductase (HMGCR) catalyzes the rate-limiting step of cholesterol biosynthesis. This enzyme is the target of the widely available cholesterol lowering statins. In this population-based case-control study, the frequencies of -911 C>A polymorphism (rs3761740) of the HMGCR gene in patients with coronary heart disease (CHD) and healthy subjects were investigated and the correlations between the different genotypes and hypercholesterolemia with cardiovascular risk factors were analyzed.