Peripheral insulin resistance levels in non-obese hypertensive patients and normotensive obese patients NONOBEZ HIPERTANSIF HASTALARDA VE NORMOTANSIF OBEZ BIREYLERDE PERIFERIK INSULIN REZISTANS DUZEYI


KARŞIDAĞ K., Altuntas Y., SATMAN İ., Dinccag N., Dincer D., Ozer E., ...More

Istanbul Tip Fakultesi Mecmuasi, vol.59, no.4, pp.20-22, 1996 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 4
  • Publication Date: 1996
  • Journal Name: Istanbul Tip Fakultesi Mecmuasi
  • Journal Indexes: Scopus
  • Page Numbers: pp.20-22
  • Istanbul University Affiliated: Yes

Abstract

In non-diabetic patients with peripheral insulin resistance (PIR): obesity and hypertension are either ends of the seeaw regarding metabolic disorders. In this study, insulin mediated glucose uptake (glucose disposal rate, GDR) considering WHO criteria, is evaluated in non-obese (body mass index, BMI<25kg/m2) hypertensive (blood pressure BP>160/90 mmHg) patients (n:10) (Group I) and in obese normotensive patients (n:6) (group II) with hyperinsulinemic euglyceamic insulin clamp technique. There are compared with non-obese and normotensive healthy subject (n:4) (Control Group). Patients with high serum cholesterol and triglyceride levels have been excluded. Insulin mediated glucose uptake levels have been found in Group 1. 3.68 0.60 and in Control Group 7.11 1.22 mg.kg-l.min-l Glucose uptake levels are found lower in Group I and Group II (p<0.001) compared with control group but the difference between group I and II was not statistically different. This suggest that the level of peripheral insulin is similar in the hypertensive non-obese and normotensive obese individuals.