Zinc Prevents Ethanol-Induced Oxidative Damage in Lingual Tissues of Rats

Bayrak B. B., Arda-Pirincci P., Bolkent Ş., Yanardag R.

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.200, sa.2, ss.720-727, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 200 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s12011-021-02682-6
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Pollution Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.720-727
  • Anahtar Kelimeler: Ethanol, Zinc sulfate, Metallothionein, Oxidative stress, Lingual tissue, Rat, ALPHA-TOCOPHEROL ACETATE, GASTRIC-MUCOSAL INJURY, LIPID-PEROXIDATION, SODIUM SELENATE, ASCORBIC-ACID, ORAL-MUCOSA, STRESS, EXPOSURE, METABOLISM, TONGUE
  • İstanbul Üniversitesi Adresli: Evet

Özet

The current study was designed to investigate the effects of zinc sulfate on cell proliferation, metallothionein (MT) immunoreactivity and antioxidant system against acute ethanol-induced oxidative damage in tongue tissues of rats. Wistar albino male rats, 2.5 to 3.0 months, were divided into four groups: Group I (n = 8), intact control rats; group II (n = 8), control animals given only zinc sulfate (100 mg/kg/day, for 3 consecutive days); group III (n = 14), animals given 1 mL absolute ethanol; group IV (n = 11), animals given zinc sulfate and absolute ethanol at the same dose and time. Animals were sacrificed under anesthesia 2 h after ethanol administration or 4 h after the last zinc sulfate treatment. Ethanol administration caused a marked decrease in the number of MT immunopositive cells and the proliferating cells in the lingual epithelium. A statistically significant decline in reduced glutathione levels, catalase activity and superoxide dismutase activities was also observed, whereas a significant elevation of lipid peroxidation levels and lactate dehydrogenase activities was detected in the ethanol group. In contrast, these changes were reversed by administration of zinc sulfate to ethanol-treated rats. In conclusion, it shows that zinc sulfate has therapeutic effects on acute ethanol-induced oxidative damage in the tongue tissues of rats.