Akademik Veri Yönetim Sistemi
Journal of Turkish Spinal Surgery, cilt.35, sa.1, ss.13-18, 2024 (Scopus)
Objective: Spinal cord injury (SCI) disrupts nerve axons with devastating neurological consequences. However, there is no effective clinical treatment. The purpose of this study was to investigate the effects of the anti-inflammatory, antioxidative, and neuroprotective characteristics of alverine on traumatic spinal injury in a rat model. Materials and Methods: A total of 36 Wistar albino rats, each weighing 300-400 g, were divided into four treatment groups. In Group 1 (sham/control, n=9), only laminectomy was performed. In Group 2 (SCI, n=9), SCI was simulated after laminectomy. In Group 3 (SCI + saline, n=9), physiological saline solution was injected after SCI was induced. In Group 4 (SCI + aloperine), aloperine was administered after SCI was induced. SCI was established using the weight drop technique after laminectomy. Results: Neurological examination scores were significantly better in the aloperine-treated group than in Groups 2 and 3. SCI significantly increased serum and spinal cord tissue glutathione peroxidase, total oxidant status, 8-hydroxiguanosine, and interleukin-6 levels. These levels were successfully reduced with alverine administration. Interleukin-10 and total antioxidant status levels also decreased with alverine administration. Increased histopathological spinal cord damage score and apoptotic index in Groups 2 and 3 were significantly decreased in Group 4. Conclusion: Aloperine reduced apoptosis and increased anti-inflammatory and antioxidative mediator levels, which protected the SCI rat model against secondary nerve injury.