Cytotoxic activity of the fruit extracts of Heptaptera anatolica (Boiss.) Tutin

Tosun F., Miski M.

ACTA PHARMACEUTICA TURCICA, vol.60, no.2, pp.125-128, 2022 (Peer-Reviewed Journal)

  • Publication Type: Article / Article
  • Volume: 60 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.23893/1307-2080.aps.6009
  • Journal Name: ACTA PHARMACEUTICA TURCICA
  • Journal Indexes: International Pharmaceutical Abstracts
  • Page Numbers: pp.125-128
  • Istanbul University Affiliated: Yes

Abstract

Cytotoxic activities of the fruit extracts of Heptaptera anatolica (Boiss.) Tutin were investigated on the colon cancer COLO205 and KM12 cell lines. The dichloromethane extract of the fruits of H. anatolica showed the best cytotoxic activities with IC50 values of 17.9 and 15.1 ug/mL on the COLO205 and KM12 cell lines, respectively. Whereas, the ethyl acetate extract of the fruits showed moderate cytotoxic activity with IC50 values of 23.4 ug/mL against the KM12 cell lines.