Ketamine and its combinations with valproate and carbamazepine are ineffective against convulsions induced by atropine treatment and food intake in fasted mice

Gozuacik, Neriman; Turkmen, Asli; NURTEN, ASİYE; Enginar, Nurhan

doi:10.22038/ijbms.2019.33890.8062

Ketamine and its combinations with valproate and carbamazepine are ineffective against convulsions induced by atropine treatment and food intake in fasted mice

Atıf İçin Kopyala

Gozuacik N., Turkmen A. Z., NURTEN A., Enginar N.

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, cilt.22, sa.3, ss.310-314, 2019 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 22 Sayı: 3
Basım Tarihi: 2019
Doi Numarası: 10.22038/ijbms.2019.33890.8062
Dergi Adı: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.310-314
İstanbul Üniversitesi Adresli: Evet

Özet

Objective(s): Fasted rodents treated with antimuscarinics develop convulsions after refeeding. Food deprivation for 48 hr produces changes in [3H]glutamate binding suggesting glutamatergic contribution to the underlying mechanism of the seizures that are somewhat unresponsive to antiepileptics. Studies in animals and epileptic patients yielded considerable information regarding the anticonvulsant effect of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist ketamine. Thus, this study evaluated the efficacy of ketamine and its combinations with valproate and carbamazepine on convulsions in fasted animals.