Ketamine and its combinations with valproate and carbamazepine are ineffective against convulsions induced by atropine treatment and food intake in fasted mice

Gozuacik, Neriman; Turkmen, Asli; NURTEN, ASİYE; Enginar, Nurhan

doi:10.22038/ijbms.2019.33890.8062

Ketamine and its combinations with valproate and carbamazepine are ineffective against convulsions induced by atropine treatment and food intake in fasted mice

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Gozuacik N., Turkmen A. Z., NURTEN A., Enginar N.

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol.22, no.3, pp.310-314, 2019 (SCI-Expanded)

Publication Type: Article / Article
Volume: 22 Issue: 3
Publication Date: 2019
Doi Number: 10.22038/ijbms.2019.33890.8062
Journal Name: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.310-314
Istanbul University Affiliated: Yes

Abstract

Objective(s): Fasted rodents treated with antimuscarinics develop convulsions after refeeding. Food deprivation for 48 hr produces changes in [3H]glutamate binding suggesting glutamatergic contribution to the underlying mechanism of the seizures that are somewhat unresponsive to antiepileptics. Studies in animals and epileptic patients yielded considerable information regarding the anticonvulsant effect of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist ketamine. Thus, this study evaluated the efficacy of ketamine and its combinations with valproate and carbamazepine on convulsions in fasted animals.