Evaluation of kinetic effects of Gliotoxin in different breast cancer cell lines

Senol G. A., ÇALIŞKAN M., TOPÇUL M. R.

CELLULAR AND MOLECULAR BIOLOGY, sa.14, ss.76-80, 2023 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2023
  • Doi Numarası: 10.14715/embl2023.69.14.12
  • Dergi Adı: CELLULAR AND MOLECULAR BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.76-80
  • İstanbul Üniversitesi Adresli: Evet

Özet

In the present research, the antiproliferative properties of Gliotoxin, yyhich is obtained from marine fungus and thought to be a promising metabolite, on MCF-7 and MDA-MB-231 breast cancer cells, which have different molecular subtypes, were evaluated. Different cell kinetic parameters were employed for this aim. In experiments, cell viability, cell index, mitotic index, BrdL1 labeling index, and apoptotic index were assessed. Gliotoxin concentrations of 1.5625 iiM, 3.125 iiM, and 6.25 pM Were used in studies for both cell lines. As a result of the values obtained from cell viability' and xCELLigence Real-'12ime Cell Analysis (RICA) System, 1.5625 aM concentration was determined as IC, dose. This concentration as applied to all other parameters and anticancer activities were observed.