INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.72, no.12, pp.968-983, 2023 (SCI-Expanded)
Article / Article
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
Breast cancer, cancer treatment, film, lung cancer, paclitaxel, quality by design, CONTROLLED-RELEASE FORMULATIONS, IN-VITRO, POLY(ETHYLENE SUCCINATE), BLENDS, NANOPARTICLES, FILMS, SYSTEM, CRYSTALLIZATION, BIOAVAILABILITY, PLASTICIZERS
Istanbul University Affiliated:
In the present study, poly(lactic acid) (PLA) and poly(ethylene succinate) (PESu) or poly(ethylene glycol) (PEG) under the framework of quality by design, were blended to produce effective sustained-release matrices for Paclitaxel delivery. A complete physicochemical characterization including weight variation, thickness, water uptake, moisture absorption, moisture loss, and hydrolytic degradation under physiological conditions, was performed. Quality by design approach was applied to study the critical parameters. In vitro cancer toxicity was studied in human cancer cell lines including lung and breast adenocarcinoma. The developed Paclitaxel-loaded films can act as a promising alternative topical matrix as an implant for breast and lung cancer treatment.