REVUE DE MEDECINE VETERINAIRE, cilt.163, sa.1, ss.7-10, 2012 (SCI-Expanded)
In this case report, a 6 month old male Cocker Spaniel dog had exhibited clinical
signs compatible with cardiac failure (tiredness and difficulties during
exercise, anorexia, abdominal pain and distension and dyspnoea) for 3
months, an important ascites with a bloodstained fluid, a marked anaemia
and great increases in the plasma AST (aspartate aminotransferase) and ALT
(alanine aminotransferase) activities. Necropsy and histopathological investigations
were performed after the spontaneous death and revealed excessive
liver enlargement and necrosis in the vicinity of the central veins, hepatocyte
disappearance and replacement with erythrocytes in hepatic cords (trabecular
lesions), sinusoid dilatations, increase in the connective tissue, collagen accumulation
in the walls of portal veins and formation of multiple blood vessels.
It was concluded that the liver injury in the dog was consistent with histological
appearance of Budd-Chiari-like syndrome.