Spectrophotometric determination of dopaminergic drugs used for Parkinson's disease, cabergoline and ropinirole, in pharmaceutical preparations

Onal A., Caglar S.

CHEMICAL & PHARMACEUTICAL BULLETIN, cilt.55, sa.4, ss.629-631, 2007 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1248/cpb.55.629
  • Dergi Adı: CHEMICAL & PHARMACEUTICAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.629-631
  • İstanbul Üniversitesi Adresli: Evet

Özet

Simple and reproducible spectrophotometric methods have been developed for determination of dopaminergic drugs used for Parkinson's disease, cabergoline (CAB) and ropinirole hydrochloride (ROP), in pharmaceutical preparations. The methods are based on the reactions between the studied drug substances and ion-pair agents [methyl orange (MO), bromocresol green (BCG) and bromophenol blue (BPB)] producing yellow colored ion-pair complexes in acidic buffers, after extracting in dichloromethane, which are spectrophotometrically determined at the appropriate wavelength of ion-pair complexes. Beer's law was obeyed within the concentration range from 1.0 to 35 mu g ml(-1). The developed methods were applied successfully for the determination of these drugs in tablets.
Spectrophotometric determination of dopaminergic drugs used for Parkinson's disease, cabergoline and ropinirole, in pharmaceutical preparations
Author(s): Onal, A (Onal, Armagan); Caglar, S (Caglar, Sena)
Source: CHEMICAL & PHARMACEUTICAL BULLETIN  Volume: 55   Issue: 4   Pages: 629-631   DOI:10.1248/cpb.55.629   Published: APR 2007
Times Cited: 10 (from Web of Science)
Cited References: 20      [ view related records ]     Citation MapCitation Map     
Abstract: Simple and reproducible spectrophotometric methods have been developed for determination of dopaminergic drugs used for Parkinson's disease, cabergoline (CAB) and ropinirole hydrochloride (ROP), in pharmaceutical preparations. The methods are based on the reactions between the studied drug substances and ion-pair agents [methyl orange (MO), bromocresol green (BCG) and bromophenol blue (BPB)] producing yellow colored ion-pair complexes in acidic buffers, after extracting in dichloromethane, which are spectrophotometrically determined at the appropriate wavelength of ion-pair complexes. Beer's law was obeyed within the concentration range from 1.0 to 35 mu g ml(-1). The developed methods were applied successfully for the determination of these drugs in tablets.
Accession Number: WOS:000246377800023