Comparison between iloprost and alprostadil for protection against ischemia/reperfusion injury in a rat model

CEVIRME D., ADADEMIR T., Kafali Basaran E., SAVLUK O. F., ELIBOL A., Erkanli Senturk G., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.48, no.3, pp.661-669, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.3906/sag-1710-74
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.661-669
  • Istanbul University Affiliated: Yes

Abstract

Background/aim: Alprostadil and iloprost are successful agents used for both pulmonary hypertension and extremity ischemia treatment. Different systemic effects of these agents may change the preferences of clinical usage. Superiority of preventing ischemia/reperfusion (IR) injury is a criterion for clinical preference of these agents. The present study was designed to compare the protective effects of alprostadil and iloprost in a rat model of IR injury.