Mycobacterium vaccae immunization to OVA sensitized pregnant BALB/c mice suppressed placental and postnatal IL-5 and inducing IFN-gamma secretion

AKKOÇ T., Eifan A. O., Ozdemir C., Yazi D., Yesil O., Bahceciler N. N., ...Daha Fazla

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, cilt.30, sa.1, ss.1-11, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1080/08923970701812159
  • Dergi Adı: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-11
  • Anahtar Kelimeler: hygiene hypothesis, interferon gamma, murine model of asthma, Mycobacterium vaccae, ovalbumin, pregnancy, ALLERGIC SENSITIZATION, ATOPIC-DERMATITIS, BCG VACCINATION, MURINE MODEL, CHILDREN, ASTHMA, INFLAMMATION, CYTOKINES, OVALBUMIN, DISEASE
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Although the development of atopy in the newborn is determined by a multitude of factors, an intense Th1 stimulus early in life could be protective by facilitating a switch away from Th2. Aimed to determine the effect of single Mycobacterium vaccae (M. vaccae) immunization to OVA-sensitized pregnant mice on IL-5 and IFN-gamma secretion from placental lymphocytes and splenocytes of offspring.