Mycobacterium vaccae immunization to OVA sensitized pregnant BALB/c mice suppressed placental and postnatal IL-5 and inducing IFN-gamma secretion
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, cilt.30, sa.1, ss.1-11, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 30 Sayı: 1
- Basım Tarihi: 2008
- Doi Numarası: 10.1080/08923970701812159
- Dergi Adı: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1-11
- Anahtar Kelimeler: hygiene hypothesis, interferon gamma, murine model of asthma, Mycobacterium vaccae, ovalbumin, pregnancy, ALLERGIC SENSITIZATION, ATOPIC-DERMATITIS, BCG VACCINATION, MURINE MODEL, CHILDREN, ASTHMA, INFLAMMATION, CYTOKINES, OVALBUMIN, DISEASE
- İstanbul Üniversitesi Adresli: Hayır
Özet
Although the development of atopy in the newborn is determined by a multitude of factors, an intense Th1 stimulus early in life could be protective by facilitating a switch away from Th2. Aimed to determine the effect of single Mycobacterium vaccae (M. vaccae) immunization to OVA-sensitized pregnant mice on IL-5 and IFN-gamma secretion from placental lymphocytes and splenocytes of offspring.