Mycobacterium vaccae immunization to OVA sensitized pregnant BALB/c mice suppressed placental and postnatal IL-5 and inducing IFN-gamma secretion


AKKOÇ T., Eifan A. O. , Ozdemir C. , Yazi D., Yesil O., Bahceciler N. N. , ...More

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, vol.30, no.1, pp.1-11, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1080/08923970701812159
  • Journal Name: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1-11
  • Keywords: hygiene hypothesis, interferon gamma, murine model of asthma, Mycobacterium vaccae, ovalbumin, pregnancy, ALLERGIC SENSITIZATION, ATOPIC-DERMATITIS, BCG VACCINATION, MURINE MODEL, CHILDREN, ASTHMA, INFLAMMATION, CYTOKINES, OVALBUMIN, DISEASE

Abstract

Although the development of atopy in the newborn is determined by a multitude of factors, an intense Th1 stimulus early in life could be protective by facilitating a switch away from Th2. Aimed to determine the effect of single Mycobacterium vaccae (M. vaccae) immunization to OVA-sensitized pregnant mice on IL-5 and IFN-gamma secretion from placental lymphocytes and splenocytes of offspring.