Synthesis and hypnotic activity of new 4-thiazolidinone and 2-thioxo-4,5-imidazolidinedione derivatives

Ergenc N., Capan G., Gunay N., Ozkirimli S., Gungor M., Ozbey S., ...Daha Fazla

ARCHIV DER PHARMAZIE, cilt.332, sa.10, ss.343-347, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 332 Sayı: 10
  • Basım Tarihi: 1999
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.343-347
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Conventionally accessible 4-[(2-(3,4-dimethoxyphenyl)ethyl] -3-thiosemicarbazide .(2) was converted to new 1-substituted benzylidene/furfurylidene-4- [2-(3,4-dimethoxyphenyl)ethyl] -3-thiosemicarbazides (3) which furnished 2-(substituted benzylidene/furfurylidene)hydrazono-3-[2-(3,4-dimethoxyphenyl)ethyl]thiazolidin-4-ones (4) and 1-(substituted benzylidene/furfurylidene)-amino-3-[2-(3,4-dimethoxyphenyl)ethyl]-2-thioxo-4, 5-imidazolidinediones (5) on reaction with chloroacetic acid and oxalyl chloride, respectively. The structure of 5 was confirmed by X-ray diffraction performed on 5a. 4 and 5 were evaluated for their potentiating effects on pentobarbital induced hypnosis. Most of the compounds caused remarkable increases in pentobarbital sleeping time.