The role of chemokine and chemokine receptor gene variants on the susceptibility and clinicopathological characteristics of bladder cancer


Kucukgergin C. , Isman F. K. , Dasdemir S. , Cakmakoglu B. , Sanli O., Gokkusu C., ...More

GENE, vol.511, no.1, pp.7-11, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 511 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.1016/j.gene.2012.09.011
  • Journal Name: GENE
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.7-11
  • Keywords: MCP-1, SDF-1, CCR5 Delta 32, CCR5 59029, CXCR4, CCR2 gene polymorphism, MONOCYTE CHEMOATTRACTANT PROTEIN-1, CCR5 PROMOTER, RISK-FACTOR, POLYMORPHISM, CXCR4, EXPRESSION, CCR2-64I, ASSOCIATION, MCP-1, IMMUNOTHERAPY

Abstract

The gene variants of the chemokine and chemokine receptor genes associated with inflammation may be involved in cancer initiation and progression. The aim of this study was to explore the possible association of monocyte chemoattractant protein-1 (MCP-1) A2518G, stromal cell derived factor 1 (SDF-1) 3'A and chemokine receptors CCR2A V64I, CCR5 Delta 32, CCR5 59029 and CXCR4 gene polymorphisms with the risk and clinicopathological characteristics of bladder cancer (BC) in a Turkish population.