Amyloid arthropathy mimicking seronegative rheumatoid arthritis in multiple myeloma: case reports and review of the literature

Alpay N., Artim-Esen B., Kamali S., Gül A., Kalayoglu-Besisik S.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, vol.16, no.4, pp.226-231, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 16 Issue: 4
  • Publication Date: 2009
  • Doi Number: 10.3109/13506120903421785
  • Journal Name: AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.226-231
  • Keywords: Polyarthralgia, amyloid arthropathy, multiple myeloma, seronegative RA, DISEASE
  • Istanbul University Affiliated: Yes

Abstract

We report two patients who suffered from symmetrical polyarthritis simulating rheumatoid arthritis. Acute phase response was almost within normal limits, and autoantibodies including rheumatoid factor were negative. Both of them were diagnosed as having amyloid arthropathy (AmyA) secondary to kappa multiple myeloma based on deposition of K-light chain-immunoreactive amyloid in biopsied tissue and Bence Jones protein in urine. Systemic AL amyloidosis may be important in the differential diagnosis of chronic polyarthralgia.