Effect of the IL-17F rs763780 Variant on Chronic Lymphocytic Leukemia and Multiple Myeloma Risk in a Turkish Cohort

NURSAL A. F., PEHLİVAN M., Kurnaz S., Pehlivan S.

ISTANBUL MEDICAL JOURNAL, vol.19, no.1, pp.39-42, 2018 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.5152/imj.2018.58751
  • Journal Name: ISTANBUL MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.39-42
  • Istanbul University Affiliated: Yes

Abstract

Introduction: Chronic lymphocytic leukemia (CLL) is one of the most common leukemias in developed countries. Multiple myeloma (MM), a clonal plasma cell disease, is the second most prevalent hematological cancer. Interleukin-17 (IL-17) can facilitate the secretion of numerous proinflammatory cytokines. The goal of the present study was to evaluate the effect of IL-17F rs763780 on CLL/MM susceptibility in a Turkish cohort.