Oxidative stress-mediated (sex-specific) loss of protection against type-2 diabetes by macrophage migration inhibitory factor (MIF)-173G/C polymorphism


Coban N., Onat A., Yildirim O., Can G. , Erginel-Unaltuna N.

CLINICA CHIMICA ACTA, cilt.438, ss.1-6, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 438
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.cca.2014.07.037
  • Dergi Adı: CLINICA CHIMICA ACTA
  • Sayfa Sayıları: ss.1-6

Özet

Background: The archetypical yet atypical cytokine macrophage migration inhibitory factor (MIF) fulfills pleiotropic immune functions in inflammatory diseases. Evidence emerging from both expression and functional studies implicates MIF in various aspects of cardiovascular diseases. We aimed to determine the covariates of MIF -173G/C polymorphism and its influence on type-2 diabetes risk in a sample representative of middle-aged Turks.