Oxidative stress-mediated (sex-specific) loss of protection against type-2 diabetes by macrophage migration inhibitory factor (MIF)-173G/C polymorphism

Coban N., Onat A., Yildirim O., Can G., Erginel-Unaltuna N.

CLINICA CHIMICA ACTA, vol.438, pp.1-6, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 438
  • Publication Date: 2015
  • Doi Number: 10.1016/j.cca.2014.07.037
  • Journal Name: CLINICA CHIMICA ACTA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1-6
  • Keywords: MIF gene, Polymorphism, apoB, Glucose, Diabetes mellitus, AUGSBURG CASE-COHORT, FACTOR MIF, METABOLIC SYNDROME, ABDOMINAL OBESITY, CORONARY-DISEASE, RISK-FACTORS, FOLLOW-UP, GENE, ASSOCIATION, VARIANTS
  • Istanbul University Affiliated: Yes

Abstract

Background: The archetypical yet atypical cytokine macrophage migration inhibitory factor (MIF) fulfills pleiotropic immune functions in inflammatory diseases. Evidence emerging from both expression and functional studies implicates MIF in various aspects of cardiovascular diseases. We aimed to determine the covariates of MIF -173G/C polymorphism and its influence on type-2 diabetes risk in a sample representative of middle-aged Turks.