The LOX-1 3'UTR188CT polymorphism and coronary artery disease in Turkish patients

Kurnaz Ö., Akadam-Teker A. B., Yilmaz-Aydogan H., Tekeli A., Isbir T.

MOLECULAR BIOLOGY REPORTS, vol.39, pp.4351-4358, 2012 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39
  • Publication Date: 2012
  • Doi Number: 10.1007/s11033-011-1222-3
  • Journal Name: MOLECULAR BIOLOGY REPORTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.4351-4358
  • Keywords: Oxidized LDL receptor-1, Coronary artery disease, Left ventricular hypertrophy, Polymorphism, LOW-DENSITY-LIPOPROTEIN, LEFT-VENTRICULAR HYPERTROPHY, ACUTE MYOCARDIAL-INFARCTION, LECTIN-LIKE, RECEPTOR-1 LOX-1, OLR1 GENE, ASSOCIATION, RISK, ATHEROSCLEROSIS, HYPERTENSION
  • Istanbul University Affiliated: Yes

Abstract

In coronary artery disease (CAD), a potentially reversible factor leading to cardiac death is left ventricular hypertrophy (LVH). The 3'untranslated region (3'UTR) 188CT polymorphism of lectin-like oxidized low-density lipoproteins receptor-1 (LOX-1) gene has been associated with an increased risk for CAD. We aim to investigate, in a Turkish population, whether 3'UTR188CT variation could affect the development of LVH in CAD patients. In a population-based case-control study, we compared 83 cases with CAD and 99 healthy controls for this polymorphism. The LOX-1 3'UTR188CT genotypes were determined by PCR-RFLP technique. LOX-1 3'UTR188 TT genotype was associated with significantly increased systolic blood pressure (P = 0.047) and risk of LVH (P = 0.014, OR: 3.541) when compared with the C allele carriers. In addition, the TT genotype was positively associated with decreased levels of HDL-cholesterol in the control subjects (P = 0.031) and increased levels of VLDL-C in the patient group (P = 0.009). The LOX-1 3'UTR188CT gene polymorphism may predispose to the development of LVH in CAD patients, dependent on blood pressure.