Akademik Veri Yönetim Sistemi
THORACIC AND CARDIOVASCULAR SURGEON, cilt.62, sa.2, ss.120-125, 2014 (SCI-Expanded)
BackgroundSquamous cell carcinomas confined to the bronchial wall (SCC-CBW) exhibit two distinct patterns of growth: superficially spreading and endobronchial mass lesions. We examined whether differences exist in the histopathological features and prognosis of SCC-CBW exhibiting different growth patterns. Materials and MethodsIn this study, 37 cases with SCC-CBW were included. Tumors were classified into two groups: superficially spreading squamous cell carcinoma (s-SCC) and nodular squamous cell carcinoma (n-SCC). For each case, the growth pattern, T and N status, lymphovascular and perineural invasions, immunohistochemical expressions of p53 and K-i-67, and survival rates were analyzed. ResultsTwenty cases were classified as s-SCC, and 17 cases were classified as n-SCC. There was a significant relationship and correlation between the length of s-SCC in the longitudinal axis and the depth of invasion (p=0.01, R=0.557). There was a statistically significant positive relationship between the depth of invasion and the nodal status (N1 involvement) (p<0.0001, R=0.71). ConclusionsSCC-CBW exhibits variable growth patterns. However, despite this variability, there are no biological or histological differences between tumors of different growth patterns, and this variability has very little, if any, effect on survival.