The effect of amifostine at pre- and postoperative irradiation damage on microvascular anastomoses, nerve regeneration and wound dealing


Aydin A., Meral R., Solakoglu S., Mezdegi A.

1st Congress of the World-Society-for-Reconstructive-Microsurgery, Taipei, Tayvan, 29 Ekim - 03 Kasım 2001, ss.19-20 identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Cilt numarası:
  • Basıldığı Şehir: Taipei
  • Basıldığı Ülke: Tayvan
  • Sayfa Sayıları: ss.19-20
  • İstanbul Üniversitesi Adresli: Hayır

Özet

A comparative study was undertaken to evaluate the possible effects of amifostine on irradiation damage to the healing of microvascular anastomoses, nerve regeneration through neurorrhaphy and flap survival, either preoperative irradiation+surgery or surgery+postoperative irradiation model in New-Guinea pigs. We observed benefical effects of amifostine on wound healing, nerve regeneration both clinically and microscopically. Amifostine appears to act with a mechanism similar to that of the endogenous thiols. Therefore, its radioprotective effect is probably mediated in part via enhancement reactions.